Author

Saba Shahin

Cedars-Sinai Medical CenterORCID 0000-0002-0576-9383Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:statistical model· 5 Research Focus:differential expression· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Alexander V. LjubimoviD· 3 shared Altan RentsendorjiD· 3 shared Bhakta Prasad GaireiD· 3 shared Debra HawesiD· 3 shared Dieu-Trang S. Fuchs· 3 shared Edward Robinson· 3 shared Jean‐Philippe VitiD· 3 shared Keith L BlackiD· 3 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Alexander V. LjubimovORCID

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Author profile →

5 papers

Recent·Most cited

Sex-specific retina-brain signatures link ERα/ERβ imbalance with gliosis in Alzheimer's disease

Saba Shahin, Jean‐Philippe Vit, Altan Rentsendorj, Dieu-Trang S. Fuchs, Natalie Swerdlow, Bhakta Prasad Gaire, Edward Robinson, Anna Kissel, Larkin Hagerman, Ayzhah Williams, Alexander V. Ljubimov, Debra Hawes, Lon S. S. Schneider, Mehdi Mirzaei, Keith L Black, , Maya Koronyo‐Hamaoui

The paper identifies sex-specific molecular and pathological differences in the retina-brain axis of Alzheimer's disease, linking estrogen receptor imbalance to female vulnerability.

bioRxiv · May 5, 2026 · PreprintNeuroscience

Synergistic retinal UCHL1 dysregulation and synaptic vulnerability reflect Alzheimer's disease severity

Altan Rentsendorj, Jean‐Philippe Vit, A. Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barrón, Anthony Rodriguez, Bhakta Prasad Gaire, Ousman Jallow, Julia Sheyn, Miyah R. Davis, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, , Maya Koronyo‐Hamaoui

The paper identifies UCHL1 dysregulation and synaptic loss in the retina as markers of Alzheimer's disease severity using integrated multi-omics analysis.

bioRxiv · Feb 5, 2026 · PreprintNeuroscience

Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina

Bhakta Prasad Gaire, Yosef Koronyo, Jean‐Philippe Vit, A. Hutton, Lalita Subedi, Dieu-Trang S. Fuchs, Natalie Swerdlow, Altan Rentsendorj, Saba Shahin, Daisy Martinon, Edward Robinson, Alexander V. Ljubimov, Julie A. Schneider, Lon S. Schneider, Debra Hawes, , Maya Koronyo‐Hamaoui

The paper identifies Chlamydia pneumoniae infection and NLRP3 inflammasome activation in Alzheimer's disease retinas, linking them to disease progression and cognitive impairment.

Nature Communications · Jan 22, 2026Peer-reviewedNeuroscience

Dynamic Transcriptomic Remodeling in Human Neural Progenitor Cells Reveals Mechanisms for Vision Preservation in Retinitis Pigmentosa Model

Saba Shahin, Shaughn Bell, Bin Lu, Somanshu Banerjee, Vivek Swarup, Hui Xu, Jason Chetsawang, Stephany Ramirez, Jorge S. Alfaro, Alex Laperle, Soshana P. Svendsen, Clive Niels Svendsen, Shaomei Wang

This study examines transcriptomic changes in grafted human neural progenitor cells and host retinal cells in a retinitis pigmentosa model, identifying mechanisms for vision preservation.

bioRxiv · Jan 6, 2025 · PreprintNeuroscience

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease

Emily Miyoshi, Samuel Morabito, Caden M. Henningfield, Sudeshna Das, Negin Rahimzadeh, Sepideh Kiani Shabestari, Neethu Michael, Nora Emerson, Fairlie Reese, Zechuan Shi, Zhenkun Cao, Shushrruth Sai Srinivasan, Vanessa M. Scarfone, Miguel A. Arreola, Jackie Lu, , Vivek Swarup

This study uses spatial transcriptomics and single-nucleus RNA-seq to compare genetic and sporadic Alzheimer's Disease, finding similar spatial and cell-type specific changes between sporadic AD and AD in Down Syndrome.

Nature Genetics · Nov 22, 2024Peer-reviewedNeuroscience