Author
Charité – Universitätsmedizin BerlinORCID 0000-0002-2939-9487Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Mehmet Gül, Alice Rossi, Christian M. T. Spahn, Gary R. Lewin, Mikhail Kudryashev
The paper presents cryo-EM structures of the naked mole-rat ribosome, revealing a stabilized split 28S rRNA and its structural context.
Nature Communications · Jul 3, 2026Peer-reviewedBiochemistry
Shannon Bareesel, Thomas J. Böddeker, Willem Bintig, Domonkos Nagy-Herczeg, Max Ruwolt, Vasiliki Syropoulou, Cristina Kroon, Patricia Kreis, Susanne Wegmann, Michal Szczepek, Christian M. T. Spahn, Patrick Scheerer, George Leondaritis, Fan Liu, Roland L. Knorr, Britta Johanna Eickholt
This study identifies PLPPR3 condensates as actin sinks that locally boost monomer concentrations, promoting actin polymerization and filopodia formation in neurons.
bioRxiv · Oct 9, 2025 · PreprintCell Biology
Fabian Schildhauer, Petra S. J. Ryl, Simon Malte Lauer, Swantje Lenz, Ayşe Berçin Barlas, Vasileios R. Ouzounidis, Kate Jeffrey, Daniel-Cosmin Marcu, Francis J. O’Reilly, Andrea Graziadei, Marchel Stuiver, Kita Schmidt, Helge Ewers, Christian M. T. Spahn, Ezgi Karaca, , Juri Rappsilber
The paper identifies AIFM1/AK2 interaction as a gatekeeper of mitochondrial ATP synthase, showing it is NADH-dependent and linked to metabolic state, with implications for mitochondrial diseases.
Molecular Cell · Jun 26, 2025Peer-reviewedBiochemistry
Ekaterina V. Borisova, Andrew G. Newman, Marta Couce-Iglesias, Rike Dannenberg, Theres Schaub, Bo Qin, Alexandra Rusanova, Marisa M. Brockmann, Janina Koch, Marieatou Daniels, Paul Turko, Olaf Jahn, David R. Kaplan, Marta Rosário, Takao Iwawaki, , Mateusz C. Ambrozkiewicz
The paper shows that Ire1α regulates mRNA translation rates, which control the identity and polarity of upper layer cortical neurons through eIF4A1 and eEF-2.
Nature Communications · Jun 7, 2024Peer-reviewedNeuroscience
Dermot Harnett, Mateusz C. Ambrozkiewicz, Ulrike Zinnall, Alexandra Rusanova, Ekaterina V. Borisova, Amelie N. Drescher, Marta Couce-Iglesias, Gabriel Villamil, Rike Dannenberg, Koshi Imami, Agnieszka Münster‐Wandowski, Beatrix Fauler, Thorsten Mielke, Matthias Selbach, Markus Landthaler, , Matthew L. Kraushar
The paper measures translation dynamics in mouse neocortex neurogenesis, revealing a critical period of translational control that regulates protein expression and neuronal differentiation.
Nature Structural & Molecular Biology · Dec 1, 2022Peer-reviewedNeuroscience
Andrea Graziadei, Fabian Schildhauer, Christian M. T. Spahn, Matthew L. Kraushar, Juri Rappsilber
This study identifies the role of Nsp1's N-terminal and linker regions in host translational shutoff by mapping their interactions with ribosomal and eIF3 components.
bioRxiv · Feb 10, 2022 · PreprintMolecular Biology
Matthew L. Kraushar, Ferdinand Krupp, Dermot Harnett, Paul Turko, Mateusz C. Ambrozkiewicz, Thiemo Sprink, Koshi Imami, Manuel Günnigmann, Ulrike Zinnall, Carlos H. Vieira-Vieira, Theres Schaub, Agnieszka Münster‐Wandowski, Jörg Bürger, Ekaterina V. Borisova, Hiroshi Yamamoto, , Christian M. T. Spahn
The paper reveals Ebp1's role in neuronal proteostasis by analyzing ribosomal architecture and proteomic changes in the developing mouse neocortex.
Molecular Cell · Dec 22, 2020Peer-reviewedNeuroscience