Sachi Kato

The human RNA-DNA interactome is cell type-specific and dynamic

The paper maps RNA-DNA interactions in 16 human cell types, showing cell-type-specific and dynamic networks that correlate with gene regulation and disease traits.

Epigenomic and transcriptomic germ-free ageing atlas reveals sterile inflammation as an intrinsic ageing feature

This study presents a single-cell epigenomic and transcriptomic atlas of aged mice under germ-free conditions, revealing sterile inflammation as an intrinsic ageing feature.

A novel genomic DNA library preparation method with low GC bias

This study introduces a new genomic DNA library preparation method that reduces GC bias and improves coverage breadth compared to existing protocols.

Machine-driven parameter optimisation of biochemical reactions

The paper optimizes biochemical reaction parameters using a nanoliter platform and computer-generated liquid transfers, revealing non-linear responses and parameter interactions.

C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution

C1 CAGE detects transcription start sites and enhancer activity in lung cancer cells, revealing subpopulations with distinct responses to TGF-β and enhancer RNA dynamics.

Single-cell transcriptomes of fluorescent, ubiquitination-based cell cycle indicator cells

The paper generates a single-cell RNA-seq dataset of HeLa cells labeled with Fucci reporters and provides an open workflow for data processing and quality control.

Targeted reduction of highly abundant transcripts with pseudo-random primers

This paper introduces pseudo-random primers to reduce abundant transcripts in sequencing libraries, improving efficiency without losing transcriptome diversity.