Author

Yan Jun Lan

RIKEN

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Jay W. ShiniD· 3 shared Tsukasa Kouno· 3 shared Chung-Chau HoniD· 2 shared Jen-Chien ChangiD· 2 shared Joachim Luginbühl· 2 shared Aki MinodaiD· 1 shared Akira HasegawaiD· 1 shared Alireza Ahmadi· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenomics

Jay W. ShinORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Epigenomic and transcriptomic germ-free ageing atlas reveals sterile inflammation as an intrinsic ageing feature

Ward Nijen Twilhaar, Jen-Chien Chang, Tommy W. Terooatea, Haruka Yabukami, Sachi Kato, Nicola A. Hetherington, Naoko Satoh‐Takayama, Alireza Ahmadi, Tsung-Han Hsieh, Prashanti Jeyamohan, Tomoko Kageyama, Yan Jun Lan, Nanako Kadono-Maekubo, Shiori Maeda, Yurina Miyajima, , Aki Minoda

This study presents a single-cell epigenomic and transcriptomic atlas of aged mice under germ-free conditions, revealing sterile inflammation as an intrinsic ageing feature.

bioRxiv · Nov 19, 2025 · PreprintGenomics

Antisense oligonucleotide-mediated perturbation of long non-coding RNA reveals functional features in stem cells and across cell types

Chi Wai Yip, Chung-Chau Hon, Kayoko Yasuzawa, Divya Mundackal Sivaraman, Jordan A. Ramilowski, Youtaro Shibayama, Saumya Agrawal, Anika Vinayak Prabhu, Callum Parr, Jessica Severin, Yan Jun Lan, Josée Dostie, Andreas Petri, Hiromi Nishiyori-Sueki, Michihira Tagami, , Jay W. Shin

The paper performs knockdown of 200 lncRNAs in human iPS cells, identifies 36 with growth inhibition, and finds molecular phenotypes in 29.3% of cases, with higher agreement in molecular than cell growth phenotypes across cell types.

Cell Reports · Dec 1, 2022Peer-reviewedGenomics

Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.

Sònia Sabaté‐Soler, Sarah Nickels, Cláudia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W. Shin, Sally A. Cowley, Jens Christian Schwamborn

This study integrates human iPSC-derived microglia into midbrain organoids, enhancing neuronal maturation and functionality through effects on synaptic remodeling and excitability.

Glia · Mar 9, 2022Peer-reviewedNeuroscience

Brainstem organoids from human pluripotent stem cells contain neural crest population

Nobuyuki Eura, Takeshi K. Matsui, Joachim Luginbühl, Masaya Matsubayashi, Hitoki Nanaura, Tomo Shiota, Kaoru Kinugawa, Naohiko Iguchi, Takao Kiriyama, Canbin Zheng, Tsukasa Kouno, Yan Jun Lan, Pornparn Kongpracha, Pattama Wiriyasermkul, Yoshihiko M. Sakaguchi, , Eiichiro Mori

This study develops human brainstem organoids containing neural crest cells and various neuron types, validated by single-cell RNA sequencing, proteomics, and electrophysiology.

bioRxiv · Nov 4, 2019 · PreprintDevelopmental Biology