Dustin Haskell

In vivo dissection of human NRXN1 isoforms reveals gain-of-function pathogenicity of schizophrenia-associated 3' deletions

The paper expresses human NRXN1 isoforms in C. elegans to assess their functional impact, finding that some 3' deletion variants cause gain-of-function pathogenicity in behavior.

Insertion of rare autism variants in synaptic genes induce novel behavioral phenotypes in C. elegans

The paper inserts rare autism variants in C. elegans synaptic genes and assesses their functional impact on behavior, revealing complex effects including loss and gain of function.

Variation in social feeding behavior and interactions among Caenorhabditis nematodes

This study examines variation in social feeding and bordering behaviors across multiple Caenorhabditis species and finds that behavioral differences do not correlate with evolutionary relatedness.

A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline enriched miRNA family

The paper identifies a noncanonical miRNA biogenesis pathway in C. elegans and humans that is Pol III-dependent, Microprocessor-independent, and Dicer-dependent, generating germline-enriched miRNAs like mir-1829 and miR-4521.

Conserved autism-associated genes tune social feeding behavior in C. elegans

This study identifies conserved autism-associated genes that regulate social feeding behavior in C. elegans through distinct synaptic mechanisms.

KH domain containing RNA-binding proteins coordinate with microRNAs to regulate Caenorhabditis elegans development

The paper investigates the functional interactions between KH domain-containing RNA-binding proteins and microRNAs in C. elegans development, showing that many KH domain genes interact with multiple miRNAs and Argonaute alg-1.