Elena Rebollo

This study develops ZBTB11 degraders to target metabolic vulnerabilities in K-Ras inhibitor-resistant PDAC, showing improved anti-cancer activity with reduced toxicity to neurons.

The paper generates human spinal cord organoids that mimic in vivo development and identifies cell intercalation as a key mechanism for secondary neurulation.

The paper identifies a transcriptional signature distinguishing low- and high-risk neuroblastomas and shows that NXPH1/-NRXN signaling inhibits metastasis while promoting tumor growth.

This study shows that phosphorylation of eEF1A2 modulates local translation and actin dynamics, influencing structural synaptic plasticity through interactions with GEF proteins and metabotropic glutamate receptor signaling.

This study shows that DYRK1A haploinsufficiency leads to impaired neocortical circuit development, contributing to neurological symptoms in a syndrome related to Down syndrome.