Alberto Parras

This paper presents a short-term performance assay in mice to evaluate functional benefits and early toxicity of anti-aging interventions, identifying compound-specific effects and highlighting potential toxicity.

This study shows that increasing RBFOX1 levels in HD mice corrects mis-splicing and reduces neuropathology and motor symptoms.

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

This study shows that partial reprogramming of dentate gyrus neurons in mice improves memory and learning in aged animals.

This study compares mouse strains for in vivo reprogramming to develop safer strategies and create a comprehensive atlas of reprogrammable strains.

The paper compares DNA methylation age in four premature aging mouse models, finding ERCC1 mice show the most significant increase in epigenetic age.

This study shows that continuous in vivo reprogramming with OSKM causes hepatic and intestinal failure, leading to premature death, but a new mouse strain reduces these effects.

This study identifies aberrant CPEB4 splicing and downstream mis-expression of SCZ-risk genes as a novel etiological mechanism in schizophrenia.

The paper compares gene expression in a mouse model of status epilepticus to human temporal lobe epilepsy tissue, finding high concordance in gene dysregulation and shared molecular features.

This study identifies widespread changes in mRNA polyadenylation in temporal lobe epilepsy, highlighting the role of CPEB4 in seizure severity and neurodegeneration.

This study shows that DYRK1A haploinsufficiency leads to impaired neocortical circuit development, contributing to neurological symptoms in a syndrome related to Down syndrome.