Author

Nathan L. Tran

Sanford Burnham Prebys Medical Discovery InstituteORCID 0000-0002-7917-3945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Alyssa L. VeranoiD· 1 shared Andrew M. LowyiD· 1 shared Anne G. BangiD· 1 shared Bart L. StakeriD· 1 shared Bram Osterhout· 1 shared Brandy M. CalhouniD· 1 shared Cara R. SchiavoniD· 1 shared Christopher A. RiceiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Alyssa L. VeranoORCID

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2 papers

Recent·Most cited

ZBTB11 Depletion Targets Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC

Nathan L. Tran, Jiewei Jiang, Mengyao Ma, Gillian E. Gadbois, Kevin Christian Montecillo Gulay, Alyssa L. Verano, Cara R. Schiavon, Elena Rebollo, Haowen Zhou, Chun‐Teng Huang, Rabi Murad, David A. Scott, Uri Manor, Anne G. Bang, Hervé Tiriac, , Fleur M. Ferguson

This study develops ZBTB11 degraders to target metabolic vulnerabilities in K-Ras inhibitor-resistant PDAC, showing improved anti-cancer activity with reduced toxicity to neurons.

Nature Chemical Biology · Aug 11, 2025Peer-reviewedCancer Biology

Naegleria fowleri: protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

Kayleigh F. Barrett, Logan M. Tillery, Jenna Goldstein, Jared W. Lassner, Bram Osterhout, Nathan L. Tran, Lily Xu, Ryan M. Young, Justin K. Craig, Ian K. H. Chun, David M. Dranow, Jan A. Abendroth, Silvia L. Delker, Douglas R Davies, Stephen J. Mayclin, , Wesley C. Van Voorhis A

The paper reports the structural determination of 19 N. fowleri proteins, identifying potential drug targets with structural differences from human homologs.

PLoS ONE · Mar 24, 2021Peer-reviewedMolecular Biology