Mark Cobbold

This paper investigates the mechanisms of ADC-immunotherapy combinations, finding that ADC-induced autophagy upregulates TNFR and M6PR, driving antitumor effects through TNF and granzyme B pathways.

This paper evaluates AZD0120, a dual-targeting BCMA/CD19 CAR-T therapy, showing improved preclinical efficacy and tumor control in multiple myeloma models.

This study develops antibody-peptide epitope conjugates (APECs) to enhance anti-tumor activity in ICB-resistant HNSCC by leveraging viral peptide-loaded MHC I proteins and protease activity.

This study compares the immunological effects of photon and proton radiation therapy in cancer patients, finding that proton therapy preserves T cell diversity and may improve survival.