De novo lipogenesis fuels adipocyte autophagosome membrane dynamics
Leslie A. Rowland, Adı́lson Guilherme, Felipe dos Santos Henriques, Chloe DiMarzio, Nicole Wetoska, Mark Kelly, Keith R. Reddig, Gregory M. Hendricks, Meixia Pan, Xianlin Han, Olga Ilkayeva, Christopher B. Newgard, Michael Czech
This study identifies de novo lipogenesis as a critical source of fatty acids for autophagosome membrane dynamics in adipocytes, showing that Fasn deficiency impairs autophagy and p62 degradation.
bioRxiv · May 25, 2022 · PreprintMolecular Biology