Pedro Faísca

Age-dependent disease tolerance to SARS-CoV-2 infection

This study shows that age-related decline in adipose tissue lipolysis reduces disease tolerance to SARS-CoV-2, increasing mortality in older mice and correlating with human COVID-19 severity.

Limited bone marrow chimerism impairs cell competition in the thymus and causes leukemia

This study shows that limited bone marrow reconstitution impairs thymic cell competition and increases leukemia risk in gamma-c-deficient mice.

A bioenergetic basis for multiorgan dysfunction in sepsis

This study identifies adipocyte lipolysis as a critical metabolic process that prevents sepsis in mice by supporting energy metabolism and thermoregulation through insulin signaling, without affecting bacterial burden.

Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish

The paper shows that optimistic and pessimistic cognitive biases in zebrafish affect stress reactivity and cancer progression, with optimists showing lower tumorigenesis.

A critical role for the ER Membrane Complex (EMC) in lipid droplet homeostasis

This study shows that the EMC3 subunit is critical for lipid droplet homeostasis in mice and Drosophila, with loss of EMC3 causing triglyceride storage defects and reduced FITM2 levels.

Monocyte control of organismal energy homeostasis

This study shows that monocyte-derived macrophages regulate energy homeostasis by responding to iron metabolism dysregulation in parenchyma cells.

The ADAM17 sheddase complex regulator iTAP modulates inflammation, epithelial repair, and tumor growth

This study shows that iTAP regulates ADAM17 activity, affecting inflammation, epithelial repair, and tumor growth in mice without causing widespread ADAM17 loss effects.