Molecular BiologyNature CommunicationsPeer-reviewed
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
Sylvia Varland, Rui Duarte Silva, Ine Kjosås…·Thomas Arnesen
The paper shows that N-terminal acetylation by NatC protects proteins from degradation, enhancing longevity and motility, and that UBR4-KCMF1 targets unacetylated N-terminal Met followed by hydrophobic residues.
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