Author

Barbara Kellen

Algarve Biomedical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1

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Research Focus:benchmarking· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Adrian DraziciD· 1 shared Alexander J. WhitworthiD· 1 shared Alexandra FaustinoiD· 1 shared Amy H.Y. TongiD· 1 shared Annelies BogaertiD· 1 shared Brenda AndrewsiD· 1 shared Camilla OsbergiD· 1 shared Chad L. MyersiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Adrian DrazicORCID

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1 paper

Recent·Most cited

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy H.Y. Tong, Simonetta Andreazza, , Thomas Arnesen

The paper shows that N-terminal acetylation by NatC protects proteins from degradation, enhancing longevity and motility, and that UBR4-KCMF1 targets unacetylated N-terminal Met followed by hydrophobic residues.

Nature Communications · Oct 27, 2023Peer-reviewedMolecular Biology