Author

Rui Duarte Silva

Algarve Biomedical CenterORCID 0000-0003-2168-8599Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Adrian DraziciD· 1 shared Alexander J. WhitworthiD· 1 shared Alexandra FaustinoiD· 1 shared Amy H.Y. TongiD· 1 shared Annelies BogaertiD· 1 shared Barbara Kellen· 1 shared Brenda AndrewsiD· 1 shared Camilla OsbergiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Adrian DrazicORCID

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1 paper

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedOct 27, 2023

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Sylvia Varland, Rui Duarte Silva, Ine Kjosås…·Thomas Arnesen

The paper shows that N-terminal acetylation by NatC protects proteins from degradation, enhancing longevity and motility, and that UBR4-KCMF1 targets unacetylated N-terminal Met followed by hydrophobic residues.

82 citationstop 1%

humanDrosophila

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