Author

Sylvia Varland

University of TorontoORCID 0000-0002-7303-2391Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Adrian DraziciD· 2 shared Amy H.Y. TongiD· 2 shared Brenda AndrewsiD· 2 shared Chad L. MyersiD· 2 shared Charles M. BooneiD· 2 shared Jason MoffatiD· 2 shared Katherine ChaniD· 2 shared Lyudmila Nedyalkova· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSystems Biology

Adrian DrazicORCID

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2 papers

Recent·Most cited

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

Maximilian Billmann, Michael Costanzo, Xiang Zhang, Arshia Zernab Hassan, Mahfuzur Rahman, Kevin R. Brown, Katherine Chan, Amy H.Y. Tong, Carles Pons, Henry N. Ward, Catherine Ross, Jolanda S. van Leeuwen, Michael Aregger, Keith A. Lawson, Barbara Mair, , Charles M. Boone

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

bioRxiv · Jun 30, 2025 · PreprintSystems Biology

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy H.Y. Tong, Simonetta Andreazza, , Thomas Arnesen

The paper shows that N-terminal acetylation by NatC protects proteins from degradation, enhancing longevity and motility, and that UBR4-KCMF1 targets unacetylated N-terminal Met followed by hydrophobic residues.

Nature Communications · Oct 27, 2023Peer-reviewedMolecular Biology