Brian Thomas Kalish

Cross-species transcriptomic atlas of X-linked Myotubular Myopathy identifies unique, treatment responsive myofiber populations

This study identifies unique myofiber populations in XLMTM using transcriptomics and shows they respond to therapeutic interventions across species.

A Generalizable, Governance-Embedded Pathway for Assessing Patient-Level Opportunities for Genetic Medicines

The paper describes a structured initiative to assess patient eligibility for genetic medicines, showing high uptake and feasibility of a multidisciplinary approach.

Maternal-fetal immune conflict contributes to male-specific impairments in a mouse model of neurodevelopmental disorders

A poly(I:C) dose at E12.5 causes placental junctional-zone breakdown, amniotic inflammation and developmental defects in a male-only subset of embryos within 24 hours, dependent on maternal IL-6.

Spatial mapping of cellular and molecular plasticity in the maternal and postpartum mouse brain

The paper maps cellular and molecular changes in the mouse brain during pregnancy and postpartum using spatial single-cell technologies, identifying three gene expression programs and linking depression risk genes to specific brain regions.

Screening rare genetic diagnoses for amenability to bespoke antisense oligonucleotide therapy development: a retrospective cohort study

The paper estimates the proportion of genetic diagnoses in a pediatric cohort that are amenable to antisense oligonucleotide therapy, finding 4.9% eligible or likely eligible.

Neuronal activity triggers widespread changes in RNA stability

The paper shows neuronal activity affects RNA stability, with HuD regulating mRNA abundance and variants linked to neurodevelopmental disorders disrupting this process.

Molecular and Epigenetic Pathways Underlying Epithelial Damage and Repair in Necrotizing Enterocolitis via Multi-omics Approach

This study uses multi-omics approaches to identify molecular and epigenetic changes in NEC, revealing Ezh2's role in maintaining intestinal stem cells and epithelial regeneration.

Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity.

This study creates a single-cell atlas of human fetal lung development, revealing epithelial cell plasticity and lineage hierarchies through scRNA-seq and spatial transcriptomics.

Perinatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography

This study maps the regenerative response to newborn brain injury in mice using spatial transcriptomics, revealing niche-specific changes in cell states, composition, and spatial organization.

Single-nucleus profiling identifies accelerated oligodendrocyte precursor cell senescence in a mouse model of Down Syndrome

The paper identifies accelerated oligodendrocyte precursor cell senescence in a mouse model of Down Syndrome and shows that reducing senescence improves cognitive function.

γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons

This study shows that γ-protocadherin isoforms are critical for synapse formation and peripheral branching in touch sensory neurons, and their loss disrupts corticospinal synapses.

Administration of amniotic fluid stem cell extracellular vesicles promotes development of fetal hypoplastic lungs by immunomodulating lung macrophages

Amniotic fluid stem cell extracellular vesicles improve fetal lung development in CDH by modulating macrophage inflammation and restoring normal gene expression.

Developmental Dynamics of RNA Translation in the Human Brain

This study maps RNA translation dynamics in the human brain using ribosome profiling, identifying thousands of novel translation events and brain-specific microproteins linked to schizophrenia.