Yuanyuan Zhang

This study shows that LIPT1 loss causes replication stress and PARP inhibitor sensitivity via PrimPol-mediated ssDNA gaps in cancer cells.

This study identifies NUDT5 as a regulator of purine metabolism and thiopurine sensitivity by interacting with PPAT, independent of its known enzymatic activity.

The paper predicts transcriptional activation domain function using graph neural networks, achieving high accuracy and outperforming existing methods.