Author

Jui‐Chung Chiang

The University of Texas Southwestern Medical CenterORCID 0000-0001-9979-8347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:mechanistic / dynamical model· 1 Assay:metabolomics· 1

Frequent Co-Authors

Yuanyuan ZhangiD· 2 shared Zeng‐Fu ShangiD· 2 shared Anthony J. DavisiD· 1 shared Ching-Cheng Hsu· 1 shared Ciara NewmaniD· 1 shared Eliot B. BlattiD· 1 shared Feng CaiiD· 1 shared Imani M. WilliamsiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Yuanyuan ZhangORCID

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2 papers

Recent·Most cited

Cell BiologyScience AdvancesPeer-reviewedMay 1, 2026

LIPT1 loss confers replication stress and PARP inhibitor sensitivity through PrimPol-mediated ssDNA gaps

Zeng‐Fu Shang, Jui‐Chung Chiang, Ching-Cheng Hsu…·Yuanyuan Zhang

This study shows that LIPT1 loss causes replication stress and PARP inhibitor sensitivity via PrimPol-mediated ssDNA gaps in cancer cells.

DOI 10.1126/sciadv.aed8013

humanproteomics

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BiochemistrySciencePeer-reviewedNov 6, 2025

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

Zheng Wu, Phong T. Nguyen, Varun Sondhi…·Ralph J. DeBerardinis

This study identifies NUDT5 as a regulator of purine metabolism and thiopurine sensitivity by interacting with PPAT, independent of its known enzymatic activity.

15 citationstop 4%

humangenetic perturbation / CRISPR

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