Giovanni Giangreco

Intravital imaging uncovers remodelling of humanised bone marrow-like niches

The paper uses intravital imaging to study dynamic remodelling of humanised bone marrow-like niches in mice, revealing vascular network formation and collagen matrix changes.

Targeting GL-Lect driven endocytosis to suppress cell plasticity in breast cancer

This study identifies GL-Lect driven endocytosis as a driver of metastatic plasticity in breast cancer and shows pharmacologic inhibition can suppress invasive phenotypes.

Cooperative and antagonistic interactions between sub-clones favour the co-existence of multiple resistance mechanisms in melanoma

This study shows that cooperative and antagonistic interactions between sub-clones in melanoma allow multiple resistance mechanisms to coexist, and identifies GSK-J4 as a potential therapeutic target.

Multicellular Calcium Waves in Cancer-Associated Fibroblasts Regulate Neuronal Mimicry and Anisotropy Leading to Immune Exclusion

The paper identifies neuronal mimicry in cancer-associated fibroblasts driven by calcium waves, leading to immune exclusion, and shows that blocking this process restores immune control.

Rapid expansion of podoplanin-positive fibroblasts following radiation limits the anti-tumour CD8+ T-cell response to radiotherapy.

This study shows that radiation-induced podoplanin-positive fibroblasts limit CD8+ T-cell access to tumour cells, reducing radiotherapy effectiveness, and that disrupting PDPN signaling enhances tumour control.