Erika Kelmer Sacramento

Sex-Dependent Proteomic Remodelling During ex vivo Degeneration of Young and Aged Murine Peripheral Nerves

This study investigates sex-dependent proteomic changes in young and aged mouse peripheral nerves during ex vivo degeneration, revealing sex-specific molecular features of nerve ageing.

Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury

The paper investigates how LPS preconditioning affects microglial proteome response to focal ischemic brain injury in mice, finding significant neuroprotection and changes in proteome patterns linked to type I interferons.

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

The paper shows that loss of TDP-43 function leads to the expression of de novo proteins from mis-spliced mRNA transcripts in ALS/FTD.

Transcriptome analysis of different strains of the turquoise killifish Nothobranchius furzeri identifies signatures associated with heritable lifespan differences

Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain

The paper shows that aging in killifish brains reduces basic amino acid-rich proteins through translation pausing, not transcription or proteasome issues, revealing a vulnerability in nucleic-acid protein biogenesis.

Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

The paper identifies RFX7 target genes through multi-omics analysis, revealing their role in tumor suppression and neuronal processes.

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.