Author

Florian Wiede

Monash UniversityORCID 0000-0001-5145-7180Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Tony TiganisiD· 2 shared Anchi S. ChanniD· 1 shared Andrea NewboldiD· 1 shared Andrew PhilpiD· 1 shared Anne BigotiD· 1 shared Christina Anne MitchelliD· 1 shared Chrysovalantou E. XirouchakiiD· 1 shared Eamon CoughlaniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPhysiology

Tony TiganisORCID

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2 papers

Recent·Most cited

A decline in skeletal muscle NOX4 abrogates adaptive homeostasis and exacerbates ageing

Chrysovalantou E. Xirouchaki, Esther García-Domínguez, Eamon Coughlan, Meagan J. McGrath, Saveen Giri, Shuwei Liang, Florian Wiede, Anne Bigot, Junichi Sadoshima, Mari Carmen Gómez‐Cabrera, Andrew Philp, Marcus Moberg, William Apró, William Roman, Christina Anne Mitchell, Tony Tiganis

This study shows that declining NOX4 in skeletal muscle with age disrupts NFE2L2 adaptive homeostasis, leading to muscle dysfunction and systemic aging, which can be mitigated by sulforaphane or exercise.

Science Advances · Jun 10, 2026Peer-reviewedPhysiology

Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition

Anchi S. Chann, Mirren Charnley, Lucas M. Newton, Andrea Newbold, Florian Wiede, Tony Tiganis, Patrick Orson Humbert, Ricky W. Johnstone, Sarah May Russell

This study uses histone deacetylase inhibition to reveal a new stage in T cell β-selection, showing how CD28, CD5, Lef1, and CD2 coordinate to regulate the checkpoint.

Life Science Alliance · Oct 25, 2022Peer-reviewedDevelopmental Biology