Dorottya Horkai

This paper shows that activating AMPK without inhibiting fatty acid synthesis preserves late-life fitness in yeast by modulating acetyl-CoA metabolism.

The paper shows that an early-life galactose diet in yeast reduces age-related gene dysregulation and senescence markers, suggesting dietary change can mimic caloric restriction benefits without calorie reduction.

This study shows that chromosome XII fragments, not ERCs, drive senescence in yeast, despite rDNA copy number increases with age.

This study shows that H3K4me3 is essential for maintaining normal gene expression levels across yeast lifespan, with COMPASS mutations reducing lifespan and causing gene expression defects.