Jamie Dean

Mechanistic modeling and machine learning identifies optimum radiotherapy schedules to prevent treatment-induced metastasis

The paper identifies optimal radiotherapy schedules to reduce metastasis by combining mechanistic modeling and machine learning with in silico clinical trials.

Live-imaging reveals Coordinated Cell Migration and Cardiac Fate Determination during Mammalian Gastrulation.

The paper tracks mesodermal cell migration and lineage during mouse gastrulation, revealing distinct progenitor behaviors and fate allocation in cardiac development.

Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

This study shows that combining radiation with Bcl-xL inhibition reduces tumor growth in preclinical models of H3K27M-altered diffuse midline glioma.

Functional consequences of a p53-MDM2-p21 incoherent feedforward loop

The paper investigates how p21 transcription variability arises through an incoherent feedforward loop involving p53 and MDM2, showing it enables rapid p21 induction and treatment-tolerant cell states.