George R. Young

The paper uses multimodal imaging to show that lysosomes act as a reservoir for PARP inhibitors, leading to heterogeneous drug distribution and response in ovarian cancer.

The paper investigates the role of Dux and MERVL in ZGA, totipotency, and cell toxicity using CRISPRa and a 2C-GFP reporter system, finding that MERVL activation contributes to expanded fate potential but not all totipotency features, while Dux-induced toxicity is independent of MERVL and involves Noxa.

This study identifies a new role for Wee1 in promoting S-phase entry by inhibiting APC/CCdh1, revealing a mechanism that impacts the efficacy and toxicity of Wee1 inhibitors in cancer treatment.

The paper shows that astrocytic RNA editing via ADAR1 modulates immune responses to alpha-synuclein, contributing to neuroinflammation in Parkinson's disease.

This paper introduces T2, a method using RNA editing to estimate transcriptional age and identify transient transcriptional programs in human cells.

The paper identifies a novel ACE2 isoform, LTR16A1-ACE2, induced by interferon, which is non-functional and does not enhance SARS-CoV-2 infection.