Author

Edcon Chang

ORCID 0000-0001-9534-0291Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:virus· 1

Frequent Co-Authors

Abhinav NathiD· 1 shared Adrien DelpaliD· 1 shared Alex MatsudaiD· 1 shared Anna CzarnaiD· 1 shared Colin Robinson· 1 shared Craig D. L. SmithiD· 1 shared David W. Baggett· 1 shared Duncan E. ScottiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Abhinav NathORCID

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2 papers

Recent·Most cited

BiochemistryRSC Medicinal ChemistryPeer-reviewedJan 1, 2026

Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase

Irene Georgiou, Colin Robinson, Sean N. O’Byrne…·Ian Hugh Gilbert

The paper develops bi-substrate inhibitors of SARS-CoV-2 nsp14 methyltransferase using structure-guided design, achieving nanomolar potency but limited cellular antiviral activity.

2 citations

virusexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintFeb 2, 2024

Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

Ellie I. James, David W. Baggett, Edcon Chang…·Abhinav Nath

The paper identifies tryptanthrin analogs as potent substoichiometric inhibitors of tau4RD aggregation, showing low nanomolar potency and demonstrating structure-activity relationship principles for tau targeting.

DOI 10.1101/2024.02.02.578649

machine learning (classical)drug response / drug discovery

𝕏 PostBluesky