Duncan E. Scott

The paper investigates false positives in SARS-CoV-2 nsp3 protease HTS assays caused by metal contamination and identifies copper and palladium as primary contaminants.

The paper develops bi-substrate inhibitors of SARS-CoV-2 nsp14 methyltransferase using structure-guided design, achieving nanomolar potency but limited cellular antiviral activity.

The paper identifies a novel false-positive mechanism in RapidFire mass spectrometry and develops a pipeline to detect and mitigate these false positives in drug discovery.