This study compares mitochondrial and cardiolipin changes in pediatric and adult failing hearts before and after VAD support, finding age-related differences in cardiolipin remodeling and mitochondrial function.

bioRxiv · Apr 5, 2026 · PreprintPhysiology

The pericardium forms as a distinct structure during heart formation

Hannah R. Moran, Obed Ofori Nyarko, Amanda Garfield, Rebecca O’Rourke, Ryenne-Christine K. Ching, Raèden Gray, Tristan M. Cobb, Fréderike W. Riemslagh, C. Ben Lovely, Brisa Peña, Alexa Burger, Carmen C. Sucharov, Christian Mosimann

This study identifies the pericardium's origin from anterior mesothelial progenitors in zebrafish, distinct from the heart field, and links pericardial stiffness to pediatric cardiomyopathies.

Nature Communications · Sep 29, 2025Peer-reviewedDevelopmental Biology

Synergistic Notch-WNT Activation Underlies Pediatric Dilated Cardiomyopathy

Obed Ofori Nyarko, Ethan Rausch, Jared R.H. Goff, Anis Karimpour‐Fard, Caitlyn S. Conard, Laura Hernandez‐Lagunas, McKenna P.A. Burns, Michael R. Bristow, Joseph C. Cleveland, Matthew L. Stone, Brisa Peña, Shelley D. Miyamoto, Brian L. Stauffer, Carmen C. Sucharov

This study identifies synergistic Notch-WNT signaling activation in pediatric dilated cardiomyopathy and shows its inhibition improves cardiac function.

bioRxiv · Jun 7, 2025 · PreprintMolecular Biology