Author

Avinash Soundararajan

Indiana University School of MedicineORCID 0000-0001-9557-0038Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Padmanabhan Paranji PattabiramaniD· 4 shared Anand SwaroopiD· 1 shared Anh H. PhamiD· 1 shared Anupam Mondal· 1 shared Carl SheridaniD· 1 shared Debasish SinhaiD· 1 shared Dominique MeyeriD· 1 shared Donna M. Pesciotta PetersiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCell Biology

Padmanabhan Paranji PattabiramanORCID

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4 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 29, 2026

Multiomic analysis of non-glaucomatous human trabecular meshwork cells.

Anh H. Pham, Isabella Moceri, Zachary A. Batz…·Kate E. Keller

This study provides a comprehensive multiomic analysis of non-glaucomatous human trabecular meshwork cells using data from multiple laboratories.

DOI 10.64898/2026.07.28.740161

humanbulk RNA-seq

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Cell BiologybioRxivPreprintApr 20, 2026

Gut-derived metabolic reprogramming drives immune aging and tissue degeneration

Sayan Ghosh, Victoria Koontz, Ying Xin…·Debasish Sinha

This study identifies a diet-induced metabolic-immune axis linking gut microbiome changes to systemic immune aging and retinal degeneration in mice and AMD patients.

DOI 10.64898/2026.04.14.718497

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Cell BiologyInvestigative Ophthalmology & Visual SciencePeer-reviewedJan 30, 2026

Loss of Cathepsin K impairs collagen biogenesis and enhances actin polymerization in trabecular meshwork

Avinash Soundararajan, Krishna Jayasankar, Emma H. Doud…·Padmanabhan Paranji Pattabiraman

This study shows that loss of Cathepsin K disrupts collagen biogenesis, ECM homeostasis, and actin polymerization in trabecular meshwork cells, potentially affecting aqueous humor outflow and IOP regulation.

1 citation

humanproteomics

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Cell BiologybioRxivPreprintFeb 16, 2024

Proteomic analysis uncovers clusterin-mediated disruption of actin-based contractile machinery in the trabecular meshwork to lower intraocular pressure

Avinash Soundararajan, Ting Wang, Padmanabhan Paranji Pattabiraman

This study identifies clusterin's role in lowering intraocular pressure by modulating actin-based contractile machinery and ECM balance in trabecular meshwork cells.

4 citations

humanproteomics

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