Padmanabhan Paranji Pattabiraman

This paper identifies an AKT1-TERT-FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE cells under stress.

This study provides a comprehensive multiomic analysis of non-glaucomatous human trabecular meshwork cells using data from multiple laboratories.

This study identifies a diet-induced metabolic-immune axis linking gut microbiome changes to systemic immune aging and retinal degeneration in mice and AMD patients.

This study shows that loss of Cathepsin K disrupts collagen biogenesis, ECM homeostasis, and actin polymerization in trabecular meshwork cells, potentially affecting aqueous humor outflow and IOP regulation.

This study identifies clusterin's role in lowering intraocular pressure by modulating actin-based contractile machinery and ECM balance in trabecular meshwork cells.

This study investigates how cholesterol affects actin dynamics and cell adhesion in trabecular meshwork cells, showing that cholesterol modulates PIP2 levels and integrin distribution, thereby influencing cell stiffness and intraocular pressure.