MicrobiologybioRxivPreprint
Genetic reassortment and diversification of host specificity have driven evolutionary trajectories of lineages of panzootic H5N1 influenza
William T. Harvey, Rute Maria Pinto, Maryn D. Brown…·Samantha Lycett
1 citation
Author
Darrell R. Kapczynski
Agricultural Research ServiceORCID 0000-0001-9559-3504Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2025 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 14 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship7 papers
Recent·Most cited
- ImmunologyFrontiers in ImmunologyPeer-reviewed
Morphologic characterization and cytokine response of chicken bone-marrow derived dendritic cells to infection with high and low pathogenic avian influenza virus
Jong-Suk Mo, Karen M. Segovia, Klaudia Chrząstek…·Darrell R. Kapczynski
This study examines the morphological changes and cytokine response of chicken bone-marrow derived dendritic cells infected with high and low pathogenic avian influenza viruses.
4 citations - MicrobiologyNaturePeer-reviewed
From birds to mammals: spillover of highly pathogenic avian influenza H5N1 virus to dairy cattle led to efficient intra- and interspecies transmission
Leonardo Cardia Caserta, Elisha Frye, Salman Latif Butt…·Diego G. Diel
This study reports the spillover of HPAI H5N1 virus to dairy cattle, showing efficient intra- and interspecies transmission and viral tropism in mammary gland epithelial cells.
527 citationstop 1% - ImmunologyVirologyPeer-reviewed
Genetic insertion of mouse Myxovirus-resistance gene 1 increases innate resistance against both high and low pathogenic avian influenza virus by significantly decreasing replication in chicken DF1 cell line
Kelsey Briggs, Klaudia Chrząstek, Karen M. Segovia…·Darrell R. Kapczynski
This study introduces mouse Mx1 into chicken cells to enhance resistance against avian influenza, showing reduced viral replication and cytopathic effects.
- BioinformaticsbioRxivPreprint
Comparative analysis of PB2 residue 627E/K/V in H5 subtypes of avian influenza viruses isolated in birds and mammals
Kelsey Briggs, Darrell R. Kapczynski
The paper compares the distribution of PB2 residue 627E/K/V in H5 AIV across avian and mammalian isolates, showing higher prevalence of E627K in mammalian sequences and H5-Gs/GD lineage.
DOI 10.1101/2023.08.11.552972 - Molecular BiologybioRxivPreprint
SARS-CoV-2 utilization of ACE2 from different bat species allows for virus entry and replication in vitro
Kelsey Briggs, Ryan Sweeney, David S. Blehert…·Darrell R. Kapczynski
This study expresses ACE2 from seven bat species in DF1 cells to assess their susceptibility to SARS-CoV-2 and its variants, showing varying replication levels and higher titers with human ACE2.
DOI 10.1101/2023.04.19.537521 - Molecular BiologyAvian DiseasesPeer-reviewed
A universal, single primer amplification protocol (R-SPA) to perform whole genome sequencing of segmented dsRNA reoviruses
Klaudia Chrząstek, Holly S. Sellers, Darrell R. Kapczynski
This paper introduces a single-primer amplification protocol (R-SPA) for whole genome sequencing of reoviruses, enabling full genome recovery from segmented dsRNA isolates.