Ming Yang

Mediator subunit MED16 cooperates with UBP1-TFCP2 to control the promoter context-dependent transcriptional activity

This study identifies MED16-UBP1 as a regulatory module with dual transcriptional activity, showing both activation of silenced genes and repression of HIV-1 transcription.

Single oocyte full-length isoform sequencing unveils the impact of transposable elements on RNA diversity and stability during oocyte maturation

The paper uses single oocyte full-length isoform sequencing to identify novel transcripts and show that transposable elements contribute to RNA isoform diversity and stability during oocyte maturation.

Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos

This study develops a single-cell multiomics sequencing method to analyze epigenetic and transcriptional dynamics in mouse preimplantation embryos, revealing regulatory networks and lineage specification mechanisms.

Comprehensive evaluation of ACE2 expression in female ovary by single-cell RNA-seq analysis

This study uses single-cell RNA-seq to evaluate ACE2 expression in ovarian tissues across developmental stages, identifying high ACE2 expression in PGCs and COC and its potential role in SARS-CoV-2 infection risk.

Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation Fetus

The paper introduces GeACT, a genomic database for human mid-gestation fetus cells, linking gene expression to chromatin states and identifying key transcription factors.

Transcriptome Landscape of Human Oocytes and Granulosa Cells Throughout Folliculogenesis

This study profiles the transcriptomes of human oocytes and granulosa cells across folliculogenesis stages, identifying stage-specific genes, cell interactions, and differences from mouse oocytes.