J. Thomas Hannich

Purine nucleobases enhance CD8+ T cell effector function

This study identifies purine nucleobases as immunometabolites that enhance CD8+ T cell effector function by enabling a metabolic switch from de novo synthesis to salvage pathway.

The solute carrier superfamily interactome

The paper maps protein-protein interactions of 396 SLC transporters using interaction proteomics and functional assays, providing a resource for understanding SLC function and drug targeting.

Metabolic mapping of the human solute carrier superfamily

The paper systematically evaluates the metabolic and transcriptional effects of SLC superfamily members, identifying new substrates and functional groups.

Functional profiling reveals a non-enzymatic role of NUDT5 in repressing purine de novo synthesis

The paper identifies a non-enzymatic role of NUDT5 in repressing purine de novo synthesis by scaffolding PPAT, with implications for cancer treatment and MTHFD1 deficiency.