Author

Constanza Alcaino

University of CambridgeORCID 0000-0001-9595-4330Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Fiona Mary GribbleiD· 3 shared Frank M. ReimanniD· 3 shared Florian T. MerkleiD· 2 shared Richard G. KayiD· 2 shared Adam Davison· 1 shared Ahmed ShaabaniD· 1 shared Amar SarkariD· 1 shared Andrian YangiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Fiona Mary GribbleORCID

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3 papers

Recent·Most cited

Cell BiologyCellular and Molecular Gastroenterology and HepatologyPeer-reviewedJan 1, 2025

Mechanisms of Activation and Serotonin release from Human Enterochromaffin Cells

Constanza Alcaino, Nunzio Guccio, Emily L. Miedzybrodzka…·Fiona Mary Gribble

This study investigates mechanisms of serotonin release from human enterochromaffin cells using organoids and functional assays, identifying key receptors and signaling pathways involved.

16 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 13, 2024

Cav3.1 is a leucine sensor in POMC neurons mediating appetite suppression and weight loss

Anthony H. K. Tsang, Nicholas Heeley, Constanza Alcaino…·Clémence Blouet

2 citations

mouseexperimental assay

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NeurosciencebioRxivPreprintApr 2, 2024

GLP-1R agonists activate human hypothalamic neurons

Simone Mazzaferro, Hsiao‐Jou Cortina Chen, Olivier Cahn…·Florian T. Merkle

This study investigates how GLP-1R agonists affect human hypothalamic neurons derived from pluripotent stem cells, finding they induce depolarization, increased firing, and gene expression changes.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky