Marcelo Boareto

This paper models the effect of V1a receptor antagonism on circadian rhythms in mice, showing it accelerates resynchronization and suggests therapeutic potential for circadian disorders.

The paper investigates the role of the protooncogene Ski in regulating the neuron-glia switch during mammalian cerebral cortex development and identifies its interaction with the BMP signaling pathway.

The paper maps transcriptional dynamics in murine cortical development, identifying lineage shifts and gene regulatory networks in neural stem cells, basal progenitors, and newborn neurons.

The paper identifies a Shh/Gli-driven three-node timer motif that controls the sequential generation of motor neurons and serotonergic neurons in the brainstem.

This study uses cell-based simulations to show that Notch signalling in developing pancreatic tissue is influenced by geometric effects and ligand expression changes, leading to distinct cell differentiation patterns.

This study identifies Notch2 and Id4 as regulators of neural stem cell quiescence in the adult hippocampus, showing their role in maintaining dormancy and affecting neurogenesis.

This study develops a stochastic model linking cell cycle progression and differentiation in adult neural stem cells, showing that their coupling maintains tissue homeostasis.

The paper proposes that positional information during vertebrate segmentation is encoded in the dynamic differences between neighboring oscillators, supported by quantitative analysis of in vivo and ex vivo mouse data.

The paper develops a mechanistic model of the her1 oscillator in zebrafish to explain how time-delayed juxtacrine coupling and autorepression drive collective oscillatory dynamics and travelling waves in somitogenesis.