Pieter Jan Koopmans

Exercise preconditioning confers skeletal muscle myometaplasticity

The paper shows that exercise preconditioning enhances skeletal muscle hypertrophy through epigenetic and metabolic changes, specifically involving Smox and Wnt signaling.

Myonuclear Dynamics After Skeletal Muscle Surgical Injury

This study investigates the origin and dynamics of displaced myonuclei in skeletal muscle after injury, finding that non-satellite cell-derived myonuclei contribute significantly to muscle repair.

Transient MYC Mimicking the Exercise Response Orchestrates Multifaceted Skeletal Muscle Adaptations

The paper shows that transient MYC activation in skeletal muscle mimics exercise-induced adaptations, leading to hypertrophy, metabolic changes, and fiber type shifts.

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle

The paper investigates the origin of displaced myonuclei in adult skeletal muscle, finding that both resident myonuclear migration and stem cell fusion contribute, depending on mechanical loading duration and fibre characteristics.

The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus

This study examines age-related differences in myonuclear multi-omic responses to muscle hypertrophy in mice, identifying transcriptional, epigenetic, and regulatory mechanisms underlying age-dependent muscle plasticity.

microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism

This study shows miR-1 regulates metabolic flexibility in skeletal muscle by controlling pyruvate metabolism, with loss of miR-1 causing metabolic inflexibility and reduced endurance.

The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates MYC as a Hypertrophic Regulator That is Sufficient for Growth

This study maps the 24-hour molecular response to resistance exercise in human muscle, identifying MYC as a key regulator of hypertrophy and mRNA levels.