Ravi Salgia

Decoding stress-induced adaptation of cancer cells in spatial confinement by integrating live-cell imaging and mathematical modeling

This study combines live-cell imaging and mathematical modeling to show how cancer cells adapt to stress in spatially confined environments, revealing cooperative and competitive strategies influenced by spatial organization and microenvironment dynamics.

Regulatory stochasticity drives opposing phenotypic outcomes in cell-fate decision networks

The paper shows how regulatory noise affects cell-fate decisions by altering phenotype occupancy in gene regulatory networks.

A Novel Syngeneic Mouse Model to Study Immune Evasion in Head and Neck Squamous Cell Carcinoma

This paper develops a novel syngeneic mouse model for HNSCC to study immune evasion and evaluates its response to immunotherapies.

The Impact of Smoking Status on the Genomic Landscape of Lung Squamous Cell Carcinoma

This study shows that non-smokers or remote smokers with squamous cell lung cancer have high rates of actionable genomic alterations, supporting the use of comprehensive genomic profiling and targeted therapies.

Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLC

Conformational dynamics of Paxillin and its multi-modal interaction with the Focal Adhesion Targeting Domain

This study reveals the conformational dynamics of Paxillin's N-domain interacting with FAK's FAT domain, showing a multi-state complex with functional implications.

Mitochondrial Dynamics Through the Lens of Nonlinear Chemical Oscillations: A Theoretical Exploration Inspired by the Belousov-Zhabotinsky Reaction

The paper models mitochondrial fission and fusion dynamics using the Belousov-Zhabotinsky reaction framework, showing oscillatory behavior and therapeutic implications in disease states.

DNA walk of specific fused oncogenes exhibit distinct fractal geometric characteristics in nucleotide patterns

The paper uses fractal geometry and DNA walk analysis to identify distinct geometric features in nucleotide patterns of oncogenes and tumour-suppressor genes, highlighting their potential in cancer research.