Pi Liu

A Novel Syngeneic Mouse Model to Study Immune Evasion in Head and Neck Squamous Cell Carcinoma

This paper develops a novel syngeneic mouse model for HNSCC to study immune evasion and evaluates its response to immunotherapies.

Tailoring Precise Genomic Integration Toward Isolate-to-Industry Strain Development for Scalable High-Titer Production of Polyhydroxyalkanoate

The paper develops genomic integration tools to engineer a halophilic strain for high-titer PHA production, achieving scalable and cost-effective industrial fermentation.

Strict OOD Antigen-to-Antibody Retrieval with CDR-Aware Slot Late Interaction

The paper introduces Ab-CASLR, a method for antigen-specific antibody retrieval under strict out-of-distribution conditions, achieving better performance than existing methods.

ProLoc: Text-guided Localization of Protein Functional Regions

ProLoc localizes protein functional regions using text guidance, outperforming existing methods on a new benchmark.

Robust Conditional Diffusion with Noisy Templates for Antibody Sequence-Structure Design

This paper introduces NT-ABDiff, a diffusion model for antibody sequence-structure design that improves CDR recovery and structural accuracy using noisy and unreliable templates.

OmicOS: A Comprehensive Omics Ecosystem Infrastructure and Agent System for the AI Era

OmicOS provides an agent-operable omics ecosystem that enables AI systems to execute and verify analyses using community methods, achieving high performance in benchmark tasks.

Double-strand break end configuration and 3D genome architecture are crucial for chromosomal translocation

This study shows that DSB end configuration and 3D genome architecture influence translocation frequency and junctional indel patterns using CRISPR/Cas9.

Cytochrome P450 Enzyme Design by Constraining Catalytic Pocket in Diffusion model

The paper designs artificial cytochrome P450 enzymes by applying a 'three-point fixation' model derived from structural and evolutionary analysis, resulting in enzymes with enhanced catalytic activity.