Angélica Liechti

Allele-specific expression is associated with lower translational efficiency in mouse embryos and stem cells

The paper investigates the relationship between allele-specific expression and translational efficiency in mouse embryos and stem cells, finding lower translational efficiency associated with allelic imbalance.

Ribosomal modification by BUD23 drives selective translational control over energy state and metabolic health

This study identifies BUD23 as a regulator of energy homeostasis by controlling translation of mitochondrial and lipogenic mRNAs, linking ribosomal modification to metabolic health.

Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms

The paper investigates diurnal regulation of IRE-containing mRNAs via IRP1 and IRP2 in mouse liver, showing that feeding rhythms drive rhythmicity even without a functional circadian clock.

A novel Smg6 mouse model reveals regulation of circadian period and daily CRY2 accumulation through the nonsense-mediated mRNA decay pathway

This study uses a Smg6 mouse model to show that NMD pathway downregulation affects circadian period length and daily CRY2 mRNA accumulation.

Functional repurposing of regulatory element activity during mammalian evolution

The paper identifies regulatory elements that have switched function between enhancers and promoters across mammalian species and shows how these changes may drive evolutionary innovations.