Joao Matos

Dbf4-dependent kinase promotes meiotic DNA end resection through cyclin-dependent kinase 12 and DNA-2 in Caenorhabditis elegans

This study identifies a DDK/CDK-12/DNA-2 signaling axis that promotes meiotic DNA end resection in C. elegans, preventing aberrant recombination outcomes.

Directional branch migration remodels the meiotic Holliday junction landscape

This study maps meiotic Holliday junctions genome-wide using HJSeq, showing directional branch migration during pachytene linked to transcription and the ZMM pathway.

RPA directly stimulates Mer3/HFM1 helicase processivity to ensure normal crossover formation in meiosis

This study identifies RPA as a direct interactor of Mer3/HFM1 helicase, showing its role in enhancing helicase processivity and crossover formation during meiosis.

FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis

The paper introduces FilamentID, a workflow to identify filament composition in cells, finding Ald4ALDH2 and Acs1ACSS2 form filaments in mitochondria and nucleus during meiosis, aiding cell recovery from stress.

The Cdc14 phosphatase controls resolution of recombination intermediates and crossover formation during meiosis

This study shows that Cdc14 phosphatase is essential for resolving meiotic recombination intermediates and crossover formation, and for proper sister chromatid segregation during meiosis.

Fully automated, sequential focused ion beam milling for cryo-electron tomography

This paper describes an automated method for preparing cryoET samples, reducing preparation time and user input while enabling high-quality lamellae for imaging and subtomogram averaging.