Katherine McJunkin

The paper identifies tts-2 as a TDMD trigger that drives decay of the mir-35-42 miRNA family in C. elegans embryos through base pairing with their seed sequence.

The paper identifies a noncanonical miRNA biogenesis pathway in C. elegans and humans that is Pol III-dependent, Microprocessor-independent, and Dicer-dependent, generating germline-enriched miRNAs like mir-1829 and miR-4521.

This study shows that miRNA Argonaute slicing has a minor role in star strand destabilization in C. elegans, with limited developmental impact and context-dependent effects.

This study shows that NHL-2's RNA-binding activity is essential for miRNA-mediated gene regulation in C. elegans, linking it to translational repression and miRISC complex function.

The paper identifies enzymes responsible for miRNA tailing in C. elegans and shows tailing does not globally regulate miRNA decay.

The paper shows that the decay of the mir-35 miRNA family in C. elegans is seed sequence-dependent and selectively regulates all members of the family during development.

This study shows that the mir-35 family of microRNAs in C. elegans is essential for embryonic viability and links maternal germline sex determination to embryonic lethality.