ImmunologybioRxivPreprint
One-step generation of TCR knock-in mice targeted to the TCRβ locus results in functional mature T lymphocytes
Jana Bilanovic, Juliana Bortolatto, Susu Duan…·Johanne Tracey Jacobsen
This paper develops a method to generate TCR knock-in mice with functional T cells by integrating TCRβ sequences into the Trb locus using AAV and CRISPR/Cas9, overcoming limitations of traditional transgenic models.
DOI 10.64898/2026.01.13.699338