Author

Hye Young Ji

Boston Children's HospitalORCID 0009-0003-0280-5021Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Organism:mouse· 1

Frequent Co-Authors

Stuart H. OrkiniD· 2 shared Aashiq Hussain KachrooiD· 1 shared Archana Verma· 1 shared Chanjae LeeiD· 1 shared Christian BrendeliD· 1 shared Daniel E. BaueriD· 1 shared Daniela Abriss· 1 shared Danilo PelliniD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersGenetics

Stuart H. OrkinORCID

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3 papers

Recent·Most cited

GeneticsCell stem cellPeer-reviewedDec 12, 2024

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

Jing Zeng, My Anh Nguyen, Pengpeng Liu…·Daniel E. Bauer

This study shows that gene editing of HSCs without ex vivo culture reduces genotoxicity while maintaining therapeutic efficacy for beta-hemoglobinopathy treatment.

34 citationstop 3%

humanCRISPR screen

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Molecular BiologybioRxivPreprintMar 30, 2023

Matrin3 mediates differentiation through stabilizing chromatin accessibility and chromatin loop-domain interactions, and YY1 mediated enhancer-promoter interactions

Tianxin Liu, Qian Zhu, Kai Yan…·Stuart H. Orkin

The paper shows Matrin3 stabilizes chromatin accessibility and loop-domain interactions, and facilitates YY1-mediated enhancer-promoter interactions during differentiation.

DOI 10.1101/2023.03.30.534959

mouseChIP-seq

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Systems BiologybioRxivPreprintSep 15, 2020

Antifungal benzimidazoles disrupt vasculature by targeting one of nine β-tubulins

Riddhiman K. Garge, Hye Young Ji, Chanjae Lee…·Edward M. Marcotte

This study identifies TUBB8 as the molecular target of benzimidazoles, revealing their mechanism of vascular disruption and potential clinical applications.

2 citations

humanexperimental assay

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