Author

Sabine Ottilie

University of California San DiegoORCID 0000-0001-9797-2612Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:plant (other)· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Amanda K. LukensiD· 3 shared Dyann F. WirthiD· 3 shared Elizabeth A. WinzeleriD· 3 shared David A. FidockiD· 2 shared Matthew AbrahamiD· 2 shared Roy M. WilliamsiD· 2 shared Alex Foy· 1 shared Andrea L. Cheung· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMicrobiology

Amanda K. LukensORCID

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3 papers

Recent·Most cited

MicrobiologyCell ReportsPeer-reviewedJul 1, 2026

Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in Plasmodium HSP90 Inhibitors

Fu-Hsuan Ko, Amanda K. Lukens, Mariana Laureano de Souza…·Elizabeth A. Winzeler

This study identifies divergent resistance mechanisms in Plasmodium HSP90 inhibitors despite shared binding sites, showing that enhanced binding can paradoxically correlate with resistance.

DOI 10.1016/j.celrep.2026.117664

plant (other)experimental assay

𝕏 PostBluesky

GeneticsbioRxivPreprintFeb 17, 2021

Defining the Yeast Resistome through in vitro Evolution and Whole Genome Sequencing

Sabine Ottilie, Madeline R. Luth, Erich Hellemann…·Elizabeth A. Winzeler

The paper identifies genetic determinants of chemical resistance in yeast using in vitro evolution and whole genome sequencing, revealing key transcription factors involved in drug resistance.

4 citations

yeastwhole-genome sequencing

𝕏 PostBluesky

GenomicsbioRxivPreprintMay 22, 2017

Mapping The Malaria Parasite Drug-Able Genome Using In Vitro Evolution And Chemogenomics

Annie N. Cowell, Eva S. Istvan, Amanda K. Lukens…·Elizabeth A. Winzeler

Whole genome sequencing reveals how Plasmodium falciparum evolves resistance to diverse compounds and identifies new antimalarial drug targets.

1 citation

humanwhole-genome sequencing

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