Eva S. Istvan

Cellular and molecular basis of PfCoronin function in artemisinin resistance in Plasmodium falciparum

This study identifies PfCoronin's role in artemisinin resistance by showing mutations impair hemoglobin uptake and modulate drug susceptibility during the ring stage of Plasmodium falciparum.

Plasmodium falciparum Niemann-Pick Type C1-Related protein relies on its physicochemical properties for membrane contact site localization required for cholesterol homeostasis

This study identifies the HLH domain of PfNCR1 as essential for its localization to narrow membrane contact sites, linking its structure to cholesterol homeostasis in Plasmodium falciparum.

The Plasmodium falciparum NCR1 membrane protein is a novel antimalarial target that exports cholesterol to maintain membrane homeostasis

This paper presents three structures of PfNCR1, a Plasmodium falciparum membrane protein, and shows it exports cholesterol to maintain membrane homeostasis, with MMV009108 inhibiting this function.

Mapping The Malaria Parasite Drug-Able Genome Using In Vitro Evolution And Chemogenomics

Whole genome sequencing reveals how Plasmodium falciparum evolves resistance to diverse compounds and identifies new antimalarial drug targets.