Qisheng Zhang

This study identifies the host soluble inositol phosphate pathway as critical for coronavirus replication and demonstrates a multi-target inhibitor that effectively suppresses viral replication in cells and mice.

The paper identifies a PLCG2 variant, PLCG2M28L, associated with increased Alzheimer's disease risk and altered microglial phenotypes, while another variant, PLCG2P522R, reduces disease risk in a mouse model.