Aulden G. Foltz

Blockade of VCAM1 or VLA4 preserves cerebrovasculature and prevents cognitive decline late after stroke

This study shows that blocking VCAM1 or VLA4 after stroke preserves vascular integrity and prevents cognitive decline by promoting blood vessel growth and restoring the blood-brain barrier.

A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase

The paper creates a spatio-temporal miRNA atlas in mice, identifying age-related miR-155-5p increase driven by microglia, independent of sex.

Spatiotemporal transcriptomic niches of complement pathway and serine protease inhibitor activation in aging and infection

This study uses spatial transcriptomics to compare aging and infection effects across multiple organs in mice, identifying shared gene expression patterns in immune pathways.

Augmentation of a neuroprotective myeloid state by hematopoietic cell transplantation

This study identifies a neuroprotective myeloid state in MS and EAE models, showing that HCT enhances this state, leading to clinical improvement and reduced demyelination.

Genetic Variants of Phospholipase C-γ 2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimers Disease

The paper identifies a PLCG2 variant, PLCG2M28L, associated with increased Alzheimer's disease risk and altered microglial phenotypes, while another variant, PLCG2P522R, reduces disease risk in a mouse model.

A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci

This study identifies molecular foci of brain aging in mice using spatiotemporal RNA-seq, showing accelerated glial aging in white matter and differential gene expression linked to neurodegenerative diseases.