Hiran A. Prag

Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy

In db/db mice, six weeks of AZD1656 improved diastolic function, cardiac metabolism and infarct size, with increased Treg infiltration and less fibrosis, without glycaemic change.

Optical Brain Pulse Monitoring for Detection of Large Vessel Occlusion Stroke in a Sheep Model

This study evaluates optical brain pulse monitoring (OBPM) in a sheep model to detect middle cerebral artery occlusion and reperfusion by analyzing changes in brain pulse waveforms.

Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons

This study shows that activating the Keap1/Nrf2 pathway reduces mitochondrial dysfunction and motor deficits in C9orf72 ALS/FTD models and patient-derived neurons.

Mitochondrial reverse electron transport in myeloid cells perpetuates neuroinflammation

The paper identifies mitochondrial reverse electron transport in myeloid cells as a driver of neuroinflammation and shows that blocking it protects the CNS in disease models.