Nadezda A. Fursova

The paper investigates the relationship between TAD boundaries and gene activity using single-cell imaging, finding they are largely uncoupled.

The paper shows that mechano-osmotic changes in pluripotent stem cells influence chromatin state and fate transitions by integrating mechanical and biochemical signals.

HiTIPS provides a flexible, open-source platform for high-throughput image analysis in cell biology, supporting customization and integration of new algorithms for tasks like segmentation, tracking, and quantification.

The paper shows that BAP1 limits H2AK119ub1 levels, which affects gene expression and Polycomb complex function, revealing a general mechanism for controlling transcriptional potential.

This study investigates the role of PRC1 catalytic activity in Polycomb system function, showing it is essential for chromatin domain formation and gene repression.

The paper shows cohesin disrupts polycomb-dependent chromosomal interactions to regulate gene repression in embryonic stem cells.

The paper investigates the role of PcG proteins in chromatin accessibility and nucleosome organization in mouse embryonic stem cells, finding that PcG proteins do not significantly affect chromatin accessibility but influence nucleosome occupancy and spacing.