Angelika Feldmann

PostChicago provides a workflow for analyzing and comparing chromatin interactions from Capture-(Hi)C data, including quality control and visualization of metaprofiles.

The paper shows that cohesin enables the developmental loss of Polycomb interactions by facilitating other regulatory contacts during cell type transitions.

The paper uses single-molecule imaging to show RNA fluctuations modulate SOX2 dynamics at the Nanog locus, revealing RNA-dependent feedback in transcriptional regulation.

This study shows that aged intestinal epithelial cells exhibit a persistent inflammation signature, marked by MHC class II upregulation and increased chromatin accessibility of inflammation-associated loci.

The paper shows that Polycomb repression during S/G2 phases restricts differentiation gene activation, allowing it to occur primarily in G1 phase in mouse ESCs.

The paper investigates the role of CDK-Mediator in gene regulation, finding it essential for Polycomb-dependent chromosomal interactions and gene priming during differentiation through distinct mechanisms.

This study investigates the role of PRC1 catalytic activity in Polycomb system function, showing it is essential for chromatin domain formation and gene repression.

The paper shows cohesin disrupts polycomb-dependent chromosomal interactions to regulate gene repression in embryonic stem cells.

The paper identifies FBXL19 as a CpG island-binding protein that recruits CDK-Mediator to developmental gene promoters in mouse ES cells, priming them for activation during lineage commitment.