Author

Alexander H. Settle

Memorial Sloan Kettering Cancer CenterORCID 0000-0001-5924-6994Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Organism:human· 1 Assay:proteomics· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Aamir MiriD· 1 shared Alexandra M. Lied· 1 shared Alireza EdrakiiD· 1 shared Ankit GuptaiD· 1 shared Benjamin Y. WineriD· 1 shared Chris K. FulleriD· 1 shared Daan VorseleniD· 1 shared Eric Chan· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Aamir MirORCID

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2 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedSep 18, 2024

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

Alexander H. Settle, Benjamin Y. Winer, Miguel de Jesus…·Morgan Huse

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.

43 citationstop 2%

proteomicsexperimental assay

𝕏 PostBluesky

Molecular BiologyGenome biologyPeer-reviewedDec 1, 2018

NmeCas9 is an intrinsically high-fidelity genome editing platform

Nadia Amrani, Xin D. Gao, Pengpeng Liu…·Erik J. Sontheimer

The paper demonstrates that NmeCas9, a Cas9 ortholog, exhibits high-fidelity genome editing in human cells with minimal off-target effects and multiple PAM compatibility.

125 citationstop 3%

humanCRISPR screen

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